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KMID : 0366220090440010058
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Korean Journal of Hematology
2009 Volume.44 No. 1 p.58 ~ p.60
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Idiopathic Thrombocytopenic Purpura in a Patient with Carcinoma of the Uterine Cervix
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Kim Hyoung-Su
Kim Jung-Han
Na Dong-Kil
Zang Dae-Young
Park Min-Jeong
Kim Hong-Bae
Lee Jong-Wook
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Abstract
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We describe here the case a patient with advanced cervix carcinoma and who developed idiopathic thrombocytopenic purpura (ITP). A 63-year-old woman with stage IV squamous cell carcinoma of the uterine cervix and that was complicated by hydronephrosis was treated palliatively with 45Gy of external beam radiation to the pelvis. About 3 years later, she developed hematochezia and severe thrombocytopenia. The laboratory examinations showed no evidence of thrombotic thrombocytopenic purpura or disseminated intravascular coagulopathy, and she was positive for serum anti-platelet antibodies. On the bone marrow examination, there was a normal number and morphology of megakaryocytes with no evidence of malignant cell infiltration. We made the clinical diagnosis of ITP, and the intravenous immunoglobulin and steroid therapy was successful. This case suggests the possibility that ITP can occur in association with advanced cervix carcinoma.
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KEYWORD
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Autoimmune thrombocytopena, Idiopathic thrombocytopenic purpura, Cervix carcinoma
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